Methylphenidate

Volume of distribution: 1.8 ± 0.91 L/kg
Clearance rate: 0.73 ± 0.28 L/h
Half-life: 1.71 hours
Tmax: 2 hours
Tmax (Concerta) 6.8±1.8 hours
Absorption half-life: 1.14 hours
Oral bioavailability: 5%
LD50 190 mg/kg
NOAEL 12.5 mg/kg
LDLo 40 mg/kg
60 mg/kg can cause Liver damage
Intraperitoneal doses of 0.25 - 1 mg/kg increase DA by 200% & NA to 400% above baseline
Oral doses of 2 mg/kg increase DA by 200% & NA to 400% above baseline
Doses of 0.3 uM increase DA by 100%
Doses of 1 uM increase DA by ~200%
Estimated minimum detection level 0.0005 mg/L (own data)
Adderall XR and Methylphenidate (racemic) are the same strength (equivalency)
Adderall is twice as powerful as Methylphenidate (racemic)
DexMethylphenidate is 10-fold more potent than Methylphenidate
Concerta is l-methylphenidate and d-methylphenidate racemic, 22% instantly releases then 78% slowly releases.