Kava

For learning/research purposes only
Kavain Injection:
Volume of distribution = 2.7 L/kg
Clearance rate = 89 mL/min
Half-life = 31.2 minutes
Tmax = 10 minutes
Absorption half-life = 2.5 minutes
Kavain Oral:
Half-life = 1.3 hours
Tmax = .88 hours
Absorption half-life = 20 minutes
Volume of distribution = 0.085 L/kg
Bioavailability = 50%
Piper Methysticum NOAEL = 24 mg/kg
500 mg/kg results in liver damage
Minimum effective dosage: 70 mg
Increases Dopamine by 25%-50%