THC/THCA

THC LD50 = 40 mg/kg

THC increases dopamine by 50% at 1 mg/kg

Cannabinoid 1 receptors start to return to normal after 2 days, and reach baseline within 4 weeks

Smoked 

Half-life: 7 minutes source

I.V. half-life: 22 minutes 

Cleared from plasma 20 minutes after inhalation

Tmax 3±1 (3-10)

Absorption half-life 0.5 minutes

Inhaled bioavailability: 55 +- 37%

Oral

Half-life 2 ± 0.3 hours

Tmax 2.6 hour

Absorption half-life 1.6 hours

Bioavailability 15%

THCA:

Half-life 3.4 ± 0.9 hours

Tmax 15 minutes

Absorption half-life 2.3 minutes

0.1 mg/kg increases anxiety

50 ug/kg smoked causes altered visual, auditory, and time perception

200 ug/kg causes psychosis

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