THC LD50 = 40 mg/kg
THC increases dopamine by 50% at 1 mg/kg
Cannabinoid 1 receptors start to return to normal after 2 days, and reach baseline within 4 weeks
Smoked
Half-life: 7 minutes source
I.V. half-life: 22 minutes
Cleared from plasma 20 minutes after inhalation
Tmax 3±1 (3-10)
Absorption half-life 0.5 minutes
Inhaled bioavailability: 55 +- 37%
Oral
Half-life 2 ± 0.3 hours
Tmax 2.6 hour
Absorption half-life 1.6 hours
Bioavailability 15%
THCA:
Half-life 3.4 ± 0.9 hours
Tmax 15 minutes
Absorption half-life 2.3 minutes
0.1 mg/kg increases anxiety
50 ug/kg smoked causes altered visual, auditory, and time perception
200 ug/kg causes psychosis
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