Half-life: 0.85 hours
Volume of Distribution: 0.76 +/- 0.26l/kg ref
Clearance Rate: 0.62 +/- 0.27 L/h/kg
o.m. = every morning
IR Tmax o.m.: 32 minutes ref
DR Tmax o.m.: 97 minutes
Absorption half-life: 10.5 minutes
Tmax: 1.9 hours (old, but still keeping it here)ref
Increases gastric pH by 5 (7 pH)
Gastric pH increased from 2.4 to 6.5 (4.1 pH increase) with 1 mg/kg, and 2.2 to 6.9 (4.7 pH increase) with 2 mg/kg.
https://www.redalyc.org/journal/2950/295047693006/html/See Fig. 1
PPIs (omeprazole) decreased dextroamphetamine's median tmax by 1.25 hours (from 4 to 2.75 hours) when administered as Adderall XR.
PPIs (omeprazole) decreased levoamphetamines's median tmax by 2.5 hours (from 5.5 to 3 hours) when administered as Adderall XR.
Source for above: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=35744538-1704-4ee0-954d-52710cf3456d&type=display
Fig. 7.7
Due to covalent bonding to ATPase pump, the duration of action for omeprazole is 28 hours (significantly longer than the half-life).
https://www.sciencedirect.com/topics/medicine-and-dentistry/proton-pump-inhibitor
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